High Disk Latency (Single Guest only)

I have a single guest machine that alerts several times per week on the metric "VM Max Total Disk Latency".  We have the trigger set to being above 50 for 5 min is a warning and above 75 for 5 min is an alert.

I've attached a screenshot of the performance data for this metric alone for the past 5 days.  We also monitor simlar metric in the guest.  The operating system is Server 2003.

I have checked the alignment in the VM using vDisk Informer and it does tell me there's an offset (see screenshot).  Would this affect the disk latency that bad?

I've spot-checked a few other machines that run the same OS and they have the same offset and do not have this issue.

Any ideas?

TIA